Is it necessary to prescribe antibiotics in impacted third molar surgical removal?: comparative study between prescribing patterns.

Izuzquiza I, Jamtøy KA, Fossland NP, Martínez-Padilla I, Falahat F, Alou L, Prieto J, Gómez-Lus ML.2016 Nov 22. pii: izuzquiza22nov20162 Rev Esp Quimioter.

A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications.

Cabal B, Alou L, Cafini F, Couceiro R, Sevillano D, Esteban-Tejeda L, Guitián F, Torrecillas R, Moya JS. Sci Rep. 2014 Jun 25;4:5440. doi: 10.1038/srep05440.

Micafungin pharmacokinetic / pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration.

Maseda E, Grau S, Villagran MJ, Hernandez-Gancedo C, Lopez-Tofiño A, Roberts JA, Aguilar L, Luque S, Sevillano D, Gimenez MJ, Gilsanz F.J Antimicrob Chemother. 2014 Jun;69(6):1624-32. doi: 10.1093/jac/dku013. Epub 2014 Feb 5.

Protection of Enterococcus faecalis in mixed cultures with carbapenemase-producing Escherichia coli and Bacteroide fragilis: effect of the bacterial load.

Sevillano D, Aguilar L, Alou L, Giménez MJ, Cafini F, González N, Prieto J.2013 Sep;26(3):220-5. Rev Esp Quimioter.

Survival of human pathogenic bacteria in different types of natural mineral water.

Serrano C, Romero M, Alou L, Sevillano D, Corvillo I, Armijo F, Maraver F, J Water Health. 2012 Sep;10(3):400-5. doi: 10.2166/wh.2012.009.

Efficacy of intraoperative antiseptic scrub after nail removal surgery

Becerro de Bengoa Vallejo R, Losa Iglesias ME, Alou Cervera L, Sevillano Fernández D, Prieto Prieto J. J Eur Acad Dermatol Venereol. 2013 Jul;27(7):925-7. doi: 10.1111/j.1468-3083.2012.04675.x. Epub 2012 Aug 7

Cefditoren and ceftriaxone enhance complement-mediated immunity in the presence of specific antibodies against antibiotic-resistant pneumococcal strains.

Ramos-Sevillano E, Rodríguez-Sosa C, Cafini F, Giménez MJ, Navarro A, Sevillano D, Alou L, García E, Aguilar L, Yuste J. 2012;7(9):e44135. doi: 10.1371/journal.pone.0044135.PLoS One.

Inhibitory effect on in vitro Streptococcus oralis biofilm of a soda-lime glass containing silver nanoparticles coating on titanium alloy

Cabal B, Cafini F, Esteban-Tejeda L, Alou L, Bartolomé JF, Sevillano D, López-Piriz R, Torrecillas R, Moya JS. PLoS One. 2012;7(8):e42393. doi: 10.1371/journal.pone.0042393. Epub 2012 Aug 3.

Effect of protein binding on the activity of voriconazole alone or combined with anidulafungin against Aspergillus spp. using a time-kill methodology.

Cafini F, Sevillano D, Alou L, Gómez-Aguado F, Corcuera MT, González N, Guinea J, Prieto J.Rev Esp Quimioter. 2012 Mar;25(1):47-55.

Activity of simulated serum concentrations of daptomycin versus vancomycin during the first 24h of treatment in the presence of physiological albumin concentrations against vancomycin-susceptible, -tolerant or -intermediate-resistant Staphylococcus aureus.

Torrico M, Aguilar L, Sevillano D, Giménez MJ, Alou L, González N, Cafini F, Cleeland R, Prieto J. Int J Antimicrob Agents. 2011 Apr;37(4):332-8. doi: 10.1016/j.ijantimicag.2010.12.007.

In vitro interference of tigecycline at subinhibitory concentrations on biofilm development by Enterococcus faecalis

Maestre JR, Aguilar L, Mateo M, Giménez MJ, Méndez ML, Alou L, Granizo JJ, Prieto J. J Antimicrob Chemother. 2012 May;67(5):1155-8. doi: 10.1093/jac/dks014. Epub 2012 Feb 9

Evolving architectural patterns in microbial colonies development

Gómez-Aguado F, Alou L, Corcuera MT, Sevillano D, Alonso MJ, Gómez-Lus ML, Prieto J.Microsc Res Tech. 2011 Oct;74(10):925-30. doi: 10.1002/jemt.20977. Epub 2010 Dec 30.

Efficacy of simulated cefditoren versus amoxicillin-clavulanate free concentrations in countering intrastrain ftsI gene diffusion in Haemophilus influenzae.

González N, Aguilar L, Sevillano D, Giménez MJ, Alou L, Cafini F, Torrico M, López AM, Coronel P, Prieto J. 2016 Nov 22. pii: izuzquiza22nov20 162.Antimicrob Agents Chemother. 2011 Jun;55(6):2788-94. doi: 10.1128/AAC.01719-10.

Efficacy of intraoperative surgical irrigation with polihexanide and nitrofurazone in reducing bacterial load after nail removal surgery

Becerro de Bengoa Vallejo R, Losa Iglesias ME, Cervera LA, Fernández DS, Prieto JP. J Am Acad Dermatol. 2011 Feb;64(2):328-35. doi: 10.1016/j.jaad.2010.01.011. Epub 2010 Nov 26.

Efficacy of preoperative and intraoperative skin and nail surgical preparation of the foot in reducing bacterial load.

Becerro De Bengoa Vallejo R, Losa Iglesias ME, Alou Cervera L, Sevillano Fernández D, Prieto Prieto J. Dermatol Surg. 2010 Aug;36(8):1258-65.

Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model.

Cafini F, Yuste J, Giménez MJ, Sevillano D, Aguilar L, Alou L, Ramos-Sevillano E, Torrico M, González N, García E, Coronel P, Prieto J.2010 Aug 10;5(8):e12041. doi: 10.1371/journal.pone.0012041.PLoS One.

Cefditoren versus ceftazidime in inducer-substrate combinations for the evaluation of AmpC production in a disc approximation test

Cafini F, Aguilar L, Alou L, Giménez MJ, Sevillano D, Torrico M, González N, Coronel P, Prieto J. Rev Esp Quimioter. 2010 Jun;23(2):72-5.

Exposure-response analysis of tigecycline in pharmacodynamic simulations using different size inocula of target bacteria.

Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Torrico M, Cafini F, Garcia-Rey C, Garcia-Escribano N, Prieto J. Int J Antimicrob Agents. 2010 Aug;36(2):137-44. doi: 10.1016/j.ijantimicag.2010.03.021. Epub 2010 May 11.

Total nail ablation for onychodystrophy with optimized gauze-phenol application.

Becerro de Bengoa Vallejo R, Losa Iglesias ME, Alou Cervera L, Sevillano Fernández D, Prieto Prieto J. J Eur Acad Dermatol Venereol. 2010 Aug;24(8):936-42. Epub 2010 Feb 17.

Colonial architecture and growth dynamics of Staphylococcus aureus resistant to methicillin.

Gómez-Aguado F, Gómez-Lus ML, Corcuera MT, Alou L, Alonso MJ, Sevillano D, Val D, Palmeiro A, Iglesias N, Prieto J.Rev Esp Quimioter. 2009 Dec;22(4):224-7.

In vitro killing activity of crevicular concentrations of tinidazole plus common oral antibiotics against high-density mixed inocula of periodontal pathogens in strict anaerobic conditions.

Alou L, Giménez MJ, Manso F, Sevillano D, Cafini F, Torrico M, González N, Prieto J, Alió JJ, Aguilar L. J Periodontol. 2010 Jan;81(1):131-8. doi: 10.1902/jop.2009.090409.

Bactericidal activity of daptomycin versus vancomycin in the presence of human albumin against vancomycin-susceptible but tolerant methicillin-resistant Staphylococcus aureus (MRSA) with daptomycin minimum inhibitory concentrations of 1-2microg/mL.

Torrico M, Giménez MJ, González N, Alou L, Sevillano D, Cafini F, Prieto J, Cleeland R, Aguilar L. Int J Antimicrob Agents. 2010 Feb;35(2):131-7. doi: 10.1016/j.ijantimicag.2009.09.021. Epub 2009 Dec 16.

Impact of the consumption of ophthalmic topical antibiotics.

García S, Mori P, López A, Alou L, Martínez D, Ramos C, Gómez-Lus ML. 2010 Dec;23(4):201-5. Spanish. Rev Esp Quimioter.

In vitro interference of beta-lactams with biofilm development by prevalent community respiratory tract isolates

Maestre JR, Mateo M, Méndez ML, Aguilar L, Gimenez MJ, Alou L, Coronel P, Granizo JJ, Prieto J. Int J Antimicrob Agents. 2010 Mar;35(3):274-7. doi: 10.1016/j.ijantimicag.2009.10.020.

In vitro effect of physiological concentrations of human albumin on the antibacterial activity of tigecycline.

Alou L, Giménez MJ, Cafini F, Aguilar L, Sevillano D, González N, Torrico M, Prieto J, García-Rey C, García-Escribano N. J Antimicrob Chemother. 2009 Dec;64(6):1230-3. doi: 10.1093/jac/dkp371. Epub 2009 Oct 16.

Influence of different resistance traits on the competitive growth of Haemophilus influenzae in antibiotic-free medium and selection of resistant populations by different {beta}-lactams: an in vitro pharmacodynamic approach.

González N, Aguilar L, Alou L, Giménez MJ, Sevillano D, Torrico M, Cafini F, Coronel P, Prieto J. J Antimicrob Chemother. 2009 Jun;63(6):1215-22. doi: 10.1093/jac/dkp097. Epub 2009 Mar 22.

High protein binding and cidal activity against penicillin-resistant S. pneumoniae: a cefditoren in vitro pharmacodynamic simulation

Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Torrico M, Cafini F, Fenoll A, Coronel P, Prieto J.PLoS One. 2008 Jul 23;3(7):e2717. doi: 10.1371/journal.pone.0002717.

Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics

Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Torrico M, Cafini F, Coronel P, Prieto J.PLoS One. 2008;3(12):e3846. doi: 10.1371/journal.pone.0003846. Epub 2008 Dec 4.

Activity of serum concentrations of daptomycin vs. vancomycin against vancomycin-susceptible and resistant Enterococcus faecium in the presence of albumin physiological concentrations: an in vitro pharmacodynamic simulation.

Alou L, Aguilar L, Giménez MJ, Torrico M, Sevillano D. Eur J Clin Microbiol Infect Dis. 2008 Oct;27(10):1009-11. doi: 10.1007/s10096-008-0525-3. Epub 2008 May 21. No abstract available.

Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers.

Sevillano D, Giménez MJ, Cercenado E, Cafini F, Gené A, Alou L, Marco F, Martínez-Martínez L, Coronel P, Aguilar L.Antimicrob Agents Chemother. 2009 Jan;53(1):267-70. doi: 10.1128/AAC.00402-08. Epub 2008 Oct 27.

Decrease in bacterial load versus resistance selection of pneumococcal subpopulations by beta-lactam physiological concentrations over time: an in vitro pharmacodynamic simulation.

Cafini F, Aguilar L, Sevillano D, Giménez MJ, Alou L, Fenoll A, Echevarría O, Torrico M, González N, Coronel P, Prieto J. Microb Drug Resist. 2008 Mar;14(1):13-21. doi: 10.1089/mdr.2008.0783.

Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity.

Cafini F, Aguilar L, Alou L, Giménez MJ, Sevillano D, Torrico M, González N, Granizo JJ, Martín-Herrero JE, Prieto J. Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):679-83. doi: 10.1007/s10096-008-0493-7. Epub 2008 Feb 26

Preoperative skin and nail preparation of the foot: comparison of the efficacy of 4 different methods in reducing bacterial load

Becerro de Bengoa Vallejo R, Losa Iglesias ME, Alou Cervera L, Sevillano Fernández D, Prieto Prieto J. J Am Acad Dermatol. 2009 Dec;61(6):986-92. doi: 10.1016/j.jaad.2009.04.045. Epub 2009 Aug 7

Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness.

Soriano F, Cafini F, Aguilar L, Tarragó D, Alou L, Giménez MJ, Gracia M, Ponte MC, Leu D, Pana M, Letowska I, Fenoll A. J Antimicrob Chemother. 2008 Dec;62(6):1234-40. doi: 10.1093/jac/dkn392. Epub 2008 Sep 16.

Levofloxacin vs. azithromycin pharmacodynamic activity against S. pneumoniae and H. influenzae with decreased susceptibility to amoxicillin/clavulanic acid.

Alou L, Aguilar L, Sevillano D, Giménez MJ, González N, Echeverría O, Torrico M, Martín JE, Valdés L, Prieto J. J Chemother. 2007 Dec;19(6):670-2.

Monte Carlo simulation describing the pharmacodynamic profile of cefditoren in plasma from healthy volunteers

Granizo JJ, Sádaba B, Honorato J, Gimenez MJ, Sevillano D, Aguilar L, Coronel P.Int J Antimicrob Agents. 2008 Apr;31(4):396-8. doi: 10.1016/j.ijantimicag.2007.10.024. Epub 2008 Jan 4.

Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil

Sevillano D, Aguilar L, Alou L, Giménez MJ, Torrico M, González N, Cafini F, Relaño MT, Coronel P, Prieto J.Antimicrob Agents Chemother. 2008 Mar;52(3):1184-6. Epub 2007 Dec 26.

Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae.

Sevillano D, Giménez MJ, Alou L, Aguilar L, Cafini F, Torrico M, González N, Echeverría O, Coronel P, Prieto J.J Antimicrob Chemother. 2007 Jul;60(1):156-8. Epub 2007 May 4.

In vitro effect of the presence of human albumin or human serum on the bactericidal activity of daptomycin against strains with the main resistance phenotypes in Gram-positives.

Cafini F, Aguilar L, González N, Giménez MJ, Torrico M, Alou L, Sevillano D, Vallejo P, Prieto J. J Antimicrob Chemother. 2007 Jun;59(6):1185-9. Epub 2007 Apr 5.

Are beta-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view?

Alou L, Giménez MJ, Sevillano D, Aguilar L, González N, Echeverría O, Torrico M, Coronel P, Prieto J.J Antimicrob Chemother. 2007 Apr;59(4):652-7. Epub 2007 Mar 6.

Influence of the displacement of protein binding by ibuprofen in the activity of a third-generation cephalosporin against Streptococcus pneumoniae.

Cafini F, González N, Torrico M, Echeverría O, Sevillano D, Alou L, Giménez MJ, Aguilar L, Gómez-Lus ML. Rev Esp Quimioter. 2006 Dec;19(4):332-6. Spanish

Effects of antimicrobials on the competitive growth of Streptococcus pneumoniae: a pharmacodynamic in vitro model approach to selection of resistant populations.

Sevillano D, Aguilar L, Alou L, Giménez MJ, Echevarría O, Cafini F, Valero E, Fenoll A, Prieto J. J Antimicrob Chemother. 2006 Oct;58(4):794-801. Epub 2006 Jul 30.

A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia

Alou L, Giménez MJ, Sevillano D, Aguilar L, Cafini F, Echeverría O, Pérez-Trallero E, Prieto J. J Antimicrob Chemother. 2006 Aug;58(2):349-58. Epub 2006 Jun 16.

Azithromycin iv pharmacodynamic parameters predicting Streptococcus pneumoniae killing in epithelial lining fluid versus serum: an in vitro pharmacodynamic simulation.

Sevillano D, Alou L, Aguilar L, Echevarría O, Giménez MJ, Prieto J. J Antimicrob Chemother. 2006 Jun;57(6):1128-33. Epub 2006 Apr 14.

Combinations of PBPs and MurM protein variants in early and contemporary high-level penicillin-resistant Streptococcus pneumoniae isolates in Spain.

del Campo R, Cafini F, Morosini MI, Fenoll A, Liñares J, Alou L, Sevillano D, Cantón R, Prieto J, Baquero F; Spanish Pneumococcal Network (G3/103). J Antimicrob Chemother. 2006 May;57(5):983-6. Epub 2006 Mar 13

Correlation between in vitro and in vivo activity of levofloxacin and moxifloxacin against pneumococcal strains with different susceptibilities to fluoroquinolones.

Huelves L, Sevillano D, Martínez-Marín C, López-Casla MT, Gracia M, Alou L, del Carmen Ponte M, Prieto J, Soriano F; Spanish Pneumococcal Infection Study Network (G03/103).Int J Antimicrob Agents. 2006 Apr;27(4):294-9. Epub 2006 Mar 9.

Urine bactericidal activity against resistant Escherichia coli in an in vitro pharmacodynamic model simulating urine concentrations obtained after 2000/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin administration.

Alou L, Aguilar L, Sevillano D, Giménez MJ, Cafini F, Valero E, Relaño MT, Prieto J.J Antimicrob Chemother. 2006 Apr;57(4):714-9. Epub 2006 Feb 21.

Alterations of the penicillin-binding proteins and murM alleles of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin in Spain

Cafini F, del Campo R, Alou L, Sevillano D, Morosini MI, Baquero F, Prieto J; Spanish Pneumococcal Network (G03/103). J Antimicrob Chemother. 2006 Feb;57(2):224-9. Epub 2005 Dec 20.

Genotypic versus phenotypic characterzation, with respect to susceptibility and identification, of 17 clinical isolates of Staphylococcus lugdunensis.

Mateo M, Maestre JR, Aguilar L, Cafini F, Puente P, Sánchez P, Alou L, Giménez MJ, Prieto J.J Antimicrob Chemother. 2005 Aug;56(2):287-91. Epub 2005 Jul 1.

Specific antibodies, levofloxacin, and modulation of capsule-associated virulence in Streptococcus pneumoniae. Antimicrob Agents Chemother.

Tarragó D, Lara N, Fenoll A, Casal J, Giménez MJ, Aguilar L, Sevillano D. 2005 Jul;49(7):3095-6.

Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers.

Alou L, Aguilar L, Sevillano D, Giménez MJ, Laguna B, Echeverría O, Carcas A, Lubomirov R, Casal J, Prieto J. J Antimicrob Chemother. 2005 May;55(5):742-7. Epub 2005 Mar 10.

Is there a pharmacodynamic need for the use of continuous versus intermittent infusion with ceftazidime against Pseudomonas aeruginosa? An in vitro pharmacodynamic model.

Aguilar L, Sevillano D, Giménez MJ, Echeverría O, Gómez-Lus ML, Prieto J. J Antimicrob Chemother. 2005 Feb;55(2):209-13. Epub 2005 Jan 13.

Bactericidal activity of amoxicillin against non-susceptible Streptococcus pneumoniae in an in vitro pharmacodynamic model simulating the concentrations obtained with the 2000/125 mg sustained-release co-amoxiclav formulation.

Sevillano D, Calvo A, Giménez MJ, Alou L, Aguilar L, Valero E, Carcas A, Prieto J.J Antimicrob Chemother. 2004 Dec;54(6):1148-51. Epub 2004 Oct 15.

Bactericidal activity of moxifloxacin against multidrug-resistant Streptoccocus pneumoniae at clinically achievable serum and epithelial lining fluid concentrations compared with three other antimicrobials.

Cafini F, Alou L, Sevillano D, Valero E, Prieto J; Spanish Pneumococcal Infection Study Network (G03/103). Int J Antimicrob Agents. 2004 Oct;24(4):334-8.

In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin.

Alou L, Cafini F, Sevillano D, Unzueta I, Prieto J. Int J Antimicrob Agents. 2004 May;23(5):513-6.

Increase of in vitro amoxycillin bactericidal activity by clavulanic acid against Neisseria meningitis using time-kill curves.

Anta ML, Giménez MJ, Alou L, Gómez-Lus ML, Laguna B, Aguilar L, Prieto J. 2002 Mar;19(3):249-50. Int J Antimicrob Agents.

Streptococcus pneumoniae isolates with reduced susceptibility to ciprofloxacin in Spain: clonal diversity and appearance of ciprofloxacin-resistant epidemic clones.

Alou L, Ramirez M, García-Rey C, Prieto J, de Lencastre H.2001 Oct;45(10):2955-7. Erratum in: Antimicrob Agents Chemother 2001 Dec;45(12):3678.Antimicrob Agents Chemother.

Activity of new fluoroquinolones against clinical isolates of Acinetobacter baumannii.

Valero E, Sevillano D, Calvo A, García R, Leturia A, Gómez-Lus ML. 2001 Dec;14(4):358-63.Rev Esp Quimioter.

An update on the susceptibility of Stenotrophomonas maltophilia.

Sevillano D, Valdezate S, Gómez-Lus ML.2001 Jun;14(2):138-54. Review. Rev Esp Quimioter.

Evaluation of two in vitro pharmacodynamic simulation models: microfiltration versus centrifugation-filtration

Alou L, Sevillano D, Bugella JH, Fuentes F, Gómez-Lus ML, Prieto J. Int J Antimicrob Agents. 2001 May;17(5):365-70.

In vitro susceptibility to gemifloxacin and trovafloxacin of Streptococcus pneumoniae strains exhibiting decreased susceptibility to ciprofloxacin.

Fuentes F, Giménez MJ, Marco F, Alou L, Aguilar L, Prieto J.2000 Feb;19(2):137-9.Eur J Clin Microbiol Infect Dis.

Efficacy of trovafloxacin in an in vitro pharmacodynamic simulation of an intraabdominal infection.

Alou L, Anta ML, Del Potro MG, Fuentes F, Balcabao IP, Gomez-Lus ML, Prieto J. 1999 Jul;12(2):135-9. Int J Antimicrob Agents.

Beta-lactam activity against penicillin-resistant Streptococcus pneumoniae strains exhibiting higher amoxicillin versus penicillin minimum inhibitory concentration values: an in vitro pharmacodynamic simulation.

Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Echeverría O, Torrico M, Valdes L, Coronel P, Prieto J. Chemotherapy. 2008;54(2):84-90. doi: 10.1159/000118659. Epub 2008 Feb 25.

Influence of media and testing methodology on susceptibility to tigecycline of Enterobacteriaceae with reported high tigecycline MIC.

Torrico M, González N, Giménez MJ, Alou L, Sevillano D, Navarro D, Díaz-Antolín MP, Larrosa N, Aguilar L, Garcia-Escribano N. J Clin Microbiol. 2010 Jun;48(6):2243-6. doi: 10.1128/JCM.00119-10. Epub 2010 Mar 29.

Tinidazole inhibitory and cidal activity against anaerobic periodontal pathogens

Alou L, Giménez MJ, Manso F, Sevillano D, Torrico M, González N, Granizo JJ, Bascones A, Prieto J, Maestre JR, Aguilar L. Int J Antimicrob Agents. 2009 May;33(5):449-52. doi: 10.1016/j.ijantimicag.2008.10.012. Epub 2008 Dec 20